49ers vs. Seahawks Week 12 odds and best bet: Pick San Francisco to cover on Thursday Night Football
Each of San Francisco's seven wins have been by seven-plus points. Photo by Scot Tucker/AP.

Thursday's Thanksgiving slate is wrapped up with an NFC West showdown between the San Francisco 49ers and Seattle Seahawks.

The pregame narrative: The Niners limped into their bye week on a three-game losing streak and emerged from it with back-to-back wins by 13-plus points. San Francisco also regained its divisional lead over Seattle and that gap should widen on Thursday.

Below are our 49ers vs. Seahawks odds and best bet for Week 12.

Sign up now to receive NorthStar's Best Bets newsletter.

49ers vs. Seahawks odds and best bet overview

Click link to add selection to betslip. Note: Lines have changed/market no longer available if grey.

SNF best betOddsBet now ⬇️
49ers -6.5-112Add to betslip

NFL odds as of 1:46 p.m. ET on 11/21/23.

Go to full 49ers/Seahawks betting markets.

49ers vs. Seahawks odds and best bet

Best Bet: 49ers -6.5 (-112)

San Francisco's Week 9 bye couldn't have come at a better time.

The team had dropped three straight and Deebo Samuel, Trent Williams and Christian McCaffrey were all banged up. But that trio is back healthy and the Niners look every bit like the wagon we've become accustomed to seeing the past two seasons.

NFL Thanksgiving Day boostsOddsBet now ⬇️
Lions, Cowboys & 49ers to all win by 10+ points+615 (was +560)Add to betslip
Any team on Thursday to score 50+ points+440 (was +400)Add to betslip
Goff & Love to each record 250+ passing yards & Over 48.5 points+505 (was +460)Add to betslip
Pollard and Robinson Jr. to both score a TD+485 (was +440)Add to betslip
Aiyuk & Lockett to each record 70+ receiving yards & either to score a TD+740 (was +675)Add to betslip
McCaffrey to record 25+ rushing/receiving yards & score a TD+240 (was +220)Add to betslip

San Francisco improved to 7-3 on the season after beating the Tampa Bay Buccaneers 27-14 in Week 11. Every single one of those wins has come by seven-plus points with at least 27 points scored — and Williams played in each of those games (he was inactive in two of SF's losses).

SF/SEA marketsBetting odds
49ers moneyline-305
Seahawks moneyline+235
49ers -6.5-112
Seahawks +6.5-109
Over 43 points-110
Under 43 points-110
49ers to score first and win+118
Seahawks to score first and win+350
Christian McCaffrey to score-335
Brandon Aiyuk to score+123
Zach Charbonnet to score+125
Deebo Samuel to score+132

The big man seems to be the key to Kyle Shanahan's offence and I can't picture the Seahawks having an answer for what the Niners want to do on Thursday.

Seattle has the 23rd-ranked total defence (345.6) and the 18th-ranked scoring defence (21.8). That unit is dealing with a rash of injuries and has gotten gashed twice in the past three games by the likes of the Washington Commanders and Baltimore Ravens.

And on the other side of the ball, Geno Smith hasn't inspired much confidence that he can go toe-to-toe with an elite defence like San Francisco's.

Key stat: San Francisco has won three straight games against Seattle, covering a 6.5-point spread in each of those contests.

Looking to get started? Sign up here.

NorthStar Bets editorial Insiders have no influence, direct or otherwise, over the setting of odds advertised on our platforms.