Thursday's Thanksgiving slate is wrapped up with an NFC West showdown between the San Francisco 49ers and Seattle Seahawks.
The pregame narrative: The Niners limped into their bye week on a three-game losing streak and emerged from it with back-to-back wins by 13-plus points. San Francisco also regained its divisional lead over Seattle and that gap should widen on Thursday.
Below are our 49ers vs. Seahawks odds and best bet for Week 12.
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49ers vs. Seahawks odds and best bet overview
Click link to add selection to betslip. Note: Lines have changed/market no longer available if grey.
| SNF best bet | Odds | Bet now ⬇️ |
| 49ers -6.5 | -112 | Add to betslip |
NFL odds as of 1:46 p.m. ET on 11/21/23.
Go to full 49ers/Seahawks betting markets.
49ers vs. Seahawks odds and best bet
Best Bet: 49ers -6.5 (-112)
San Francisco's Week 9 bye couldn't have come at a better time.
The team had dropped three straight and Deebo Samuel, Trent Williams and Christian McCaffrey were all banged up. But that trio is back healthy and the Niners look every bit like the wagon we've become accustomed to seeing the past two seasons.
| NFL Thanksgiving Day boosts | Odds | Bet now ⬇️ |
| Lions, Cowboys & 49ers to all win by 10+ points | +615 (was +560) | Add to betslip |
| Any team on Thursday to score 50+ points | +440 (was +400) | Add to betslip |
| Goff & Love to each record 250+ passing yards & Over 48.5 points | +505 (was +460) | Add to betslip |
| Pollard and Robinson Jr. to both score a TD | +485 (was +440) | Add to betslip |
| Aiyuk & Lockett to each record 70+ receiving yards & either to score a TD | +740 (was +675) | Add to betslip |
| McCaffrey to record 25+ rushing/receiving yards & score a TD | +240 (was +220) | Add to betslip |
San Francisco improved to 7-3 on the season after beating the Tampa Bay Buccaneers 27-14 in Week 11. Every single one of those wins has come by seven-plus points with at least 27 points scored — and Williams played in each of those games (he was inactive in two of SF's losses).
| SF/SEA markets | Betting odds |
| 49ers moneyline | -305 |
| Seahawks moneyline | +235 |
| 49ers -6.5 | -112 |
| Seahawks +6.5 | -109 |
| Over 43 points | -110 |
| Under 43 points | -110 |
| 49ers to score first and win | +118 |
| Seahawks to score first and win | +350 |
| Christian McCaffrey to score | -335 |
| Brandon Aiyuk to score | +123 |
| Zach Charbonnet to score | +125 |
| Deebo Samuel to score | +132 |
The big man seems to be the key to Kyle Shanahan's offence and I can't picture the Seahawks having an answer for what the Niners want to do on Thursday.
Seattle has the 23rd-ranked total defence (345.6) and the 18th-ranked scoring defence (21.8). That unit is dealing with a rash of injuries and has gotten gashed twice in the past three games by the likes of the Washington Commanders and Baltimore Ravens.
And on the other side of the ball, Geno Smith hasn't inspired much confidence that he can go toe-to-toe with an elite defence like San Francisco's.
Key stat: San Francisco has won three straight games against Seattle, covering a 6.5-point spread in each of those contests.
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