Chiefs vs. Colts Week 3 picks and odds: Back Kansas City to keep rolling
Kansas City could be in for another big game in Week 3. Photo by Ed Zurga

The 2-0 Kansas Chiefs travel to Indianapolis to take on a Colts team that's sitting at 0-1-1 after two battles with fellow AFC South teams.

The pregame narrative: Kansas City looks like the class of the AFC while the Colts have been a disappointment in the early going. A strong performance from Indianapolis would reestablish the home team as a playoff threat.

Check out our Chiefs vs. Colts Week 3 picks for September 25.

Chiefs vs. Colts Week 3 picks overview

PicksOddsBet now
Chiefs -5.5-110Add to betslip
Matt Ryan over 1.5 touchdowns +108Add to betslip
Chiefs over 27.5 points-125Add to betslip

Odds as of 11:13 a.m. on 09/23/2022.

Chiefs vs. Colts Week 3 picks

Best bet: Chiefs -5.5 (-110)

Entering the season this looked like a marquee matchup between two teams projected to win their division. Based on what we've seen thus far, this appears to be a colossal mismatch.

Despite the departure of Tyreek Hill, the Chiefs' passing offence has been unstoppable. Patrick Mahomes has seven touchdowns through the air with no interceptions — good for an NFL-best 127.9 passer rating.

Kansas City's offensive line has also kept him clean, allowing a single sack to prevent the team's drives from stalling. The Chiefs have also been surprisingly strong on the ground, with a running back committee led by Clyde Edwards-Helaire averaging 4.9 yards per carry.

Clyde Edwards-Helaire has been solid so far this season. Photo by Ross Franklin II/AP.

It's tough to judge the team's defence because much of their time has been spent in conservative zone shells protecting multiple-score leads. It is worth noting they throttled a respectable Arizona Cardinals offence for three quarters in Week 1 then held their own against Justin Herbert and the Los Angeles Chargers in Week 2.

The Colts are probably better than they've looked thus far, but their lack of explosive offensive weapons has us skeptical that they can keep up with the Chiefs' dominant attack — even with home-field advantage.

Key stat: In the first two games of the season the Chiefs have produced nine total touchdowns to the Colts' two.

Quick picks

Ryan over 1.5 touchdowns (+108): Ryan hasn't hit this over yet as a Colt, but both quarterbacks who've played the Chiefs this year have. Kansas City's pass defence isn't particularly leaky, but its opponents always seem to be chasing, which leads to garbage-time scores.

Michael Pittman Jr. looks like he's ready to return after missing Week 2, which should help Ryan's chances of leading a successful passing attack.

Chiefs over 27.5 points (-125): Kansas City has averaged 30.5 points per game so far this year. While they fell a single point short of this total in Week 2, they did so against a star-studded Chargers defence.

The Colts have some blue-chip defensive talent, but they're banged up as Shaquille Leonard and Yannick Ngakoue have spent all week on the injury report while DeForest Buckner has been limited in practice. The strength of Indy's defence is its front seven, and we're skeptical that a middling secondary can keep Mahomes under wraps.

NorthStar Bets editorial Insiders have no influence, direct or otherwise, over the setting of odds advertised on our platforms.