NFL Week 12 ushered in American Thanksgiving, and with no byes, there is plenty to be thankful for.
The pregame narrative: The annual Thanksgiving triple-header greeted us on Thursday and was followed by the first Black Friday game in league history (Dolphins vs. Jets). Sunday's action features a key AFC South matchup, as well as an opportunity for the Ravens to establish some divisional breathing room on Sunday Night Football.
Check out our latest NFL Week 12 odds as of November 24.
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NFL Week 12 odds
Click linked odds to add selection to your betslip.
| Matchup | Away ML odds | Home ML odds | Total |
| CAR vs. TEN (-3.5) | +155 | -190 | 36.5 |
| JAX (-1.5) vs. HOU | -121 | +100 | 47.5 |
| NE (-3.5) vs. NYG | -195 | +155 | 34 |
| NO (-1.5 vs. ATL | -121 | +100 | 41.5 |
| PIT (-2) vs. CIN | -129 | +102 | 35.5 |
| TB vs. IND (-2) | +116 | -139 | 44.5 |
| CLE vs. DEN (-1.5) | +102 | -124 | 36 |
| LAR (-2.5) vs. AZ | -130 | +108 | 45 |
| BUF vs. PHI (-3) | +143 | -175 | 48.5 |
| KC (-9) vs. LV | -420 | +320 | 43 |
| BAL (-3.5) vs. LAC | -175 | +140 | 48 |
| CHI vs. MIN (-3) | +133 | -162 | 43 |
Go to full NFL betting markets.
Week 12 matchup spotlight
This may not be the top matchup of the week in terms of brand recognition, but it's a monumental one in the standings.
Jacksonville suffered a 20-point beatdown at home against Houston back in Week 3, calling into question whether Trevor Lawrence could build off the Pro Bowl showing from his sophomore season.
Since then, the Jaguars (7-3) have won six of seven games to bump themselves back into first in the AFC South. But the Texans (6-4) are within range, and a sweep of the head-to-head series would grant Houston a critical tiebreaker in the standings.
In the long term, both under-25 quarterbacks appear to have bright futures. In the short term, their matchup on Sunday will go a long way in determining the AFC South division winner.
Key NFL Week 12 games
No one would've expected the Bills' season to be on life support entering Week 12, but given the crowded nature of the AFC playoff race, that's exactly where things stand.
Buffalo (6-5) authored a definitive and much-needed win over the Jets this past weekend, but now a huge game looms before the bye.
The reigning NFC champion Eagles have been menaces on home soil since the beginning of last season, winning 13 of 15 games in that span. They'll be on a short week, which helps the Bills, but that might not matter.
In the AFC, 11 of 16 teams have a record of .500 or better right now. The Bills are one of them, but they're currently on the outside of the playoff picture looking in.
Lamar Jackson's most reliable target is gone ... now what?
Mark Andrews suffered an ankle injury this past weekend that will likely keep him out for the rest of the season. Now Baltimore's passing game must put its faith in a rookie (Zay Flowers) and a resurgent vet (Odell Beckham Jr.) to keep the motor humming.
And of course, life is pretty good with Jackson behind the wheel.
Up next is a Chargers team that has lost back-to-back games by a field goal. Los Angeles (4-6) needs a win in the worst way, and it can usually be relied upon to at least keep things close.