NFL Week 2 odds: Chiefs are road favourites in Jacksonville
Mahomes and the Chiefs beat the Jaguars 27-20 in the playoffs last season. Photo by Ed Zurga/AP.

NFL Week 2 action is off and running.

The latest: The Minnesota Vikings and Philadelphia Eagles kicked things off on Thursday Night Football and more big matchups are on the way Sunday. The biggest is arguably taking place in Jacksonville when the Jaguars host the defending champs. We'll also see how the New York Jets respond in Dallas without Aaron Rodgers.

Check out our latest NFL Week 2 odds below as of September 15.

NFL Week 2 odds

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MatchupAway ML oddsHome ML oddsTotal
BAL @ CIN (-3.5)+145-18046.5
CHI @ TB (-3)+120-14840.5
GB @ ATL (-1.5)+108-13040
IND @ HOU (-1.5)+100-12140
KC (-3) @ JAX-182+15051
LV @ BUF (-8.5)+310-40047
LAC (-3) @ TEN-148+12345.5
SEA @ DET (-4.5)+185-23547
NYG (-4) @ AZ-215+17040
SF (-7.5) @ LAR-345+26545
NYJ @ DAL (-9)+330-45538.5
WSH @ DEN (-3.5)+155-19039
MIA (-3) @ NE-159+13246.5
NO (-3) @ CAR-175+14039.5
CLE (-2.5) @ PIT-136+11238.5

NFL odds as of 4:18 p.m. ET on 09/15/2023.

Go to full NFL betting markets.

Week 2 matchup spotlight

Chiefs vs. Jaguars

The last time these teams met, Patrick Mahomes and Co. punched their ticket to the AFC championship game in a 27-20 victory.

The fact that Jacksonville even got to that game is impressive, considering it was 3-7 after 10 games in 2022. But the Jags caught fire and it looks like they're here to stay.

Jacksonville secured a 10-point victory over the Indianapolis Colts in Week 1 and new addition Calvin Ridley exploded for 101 yards and a score.

Doug Pederson's offence is electric and Kansas City might have trouble keeping up, as odd as that sounds. The Chiefs' receiving room disappeared in Week 1 and Travis Kelce's status for this game is up in the air, though he was practicing on Wednesday.

Frank Clark's holdout is over and he'll be a welcome addition on the defensive side.

Regardless of if Kelce plays or not, this should be a close one.

Other NFL Week 2 odds

Ravens vs. Bengals

In a weekend loaded with divisional matchups, this one is among the most intriguing.

The Cincinnati Bengals managed just a field goal against the Cleveland Browns in their Week 1 blowout loss, while the Baltimore Ravens ran all over the Houston Texans in a lopsided win.

But Baltimore's victory didn't come without a price. J.K. Dobbins was diagnosed with a torn Achilles and Marcus Williams will be out for extended time with a pec injury. Those are two massive losses on both sides of the ball.

Cincinnati is dealing with problems, too, as Joe Burrow didn't look 100% following the calf strain he sustained in training camp.

NFL Week 2 odds notes

  • We've seen some big movement across a few games, with none bigger than the Cowboys and Jets. Dallas was a 3-point favourite ahead of New York's Monday nighter versus the Buffalo Bills. But that spread jumped to Cowboys -7.5 as of Tuesday morning and has moved a full 1.5 points since after confirmation that Rodgers suffered a season-ending Achilles injury. The total has plunged a whopping 6 points since last night.
  • The Pittsburgh Steelers and Browns couldn't have started their seasons more differently. The former got blown out at home by the San Francisco 49ers while the latter routed the Bengals. The Steelers have dominated the Browns in Pittsburgh for the last decade but the balance of power might be tipping in the AFC North.
  • Anthony Richardson and C.J. Stroud provide us with an all-rookie quarterback matchup on Sunday when the Indianapolis Colts head to Houston to take on the Texans as a short road dog.

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NorthStar Bets editorial Insiders have no influence, direct or otherwise, over the setting of odds advertised on our platforms.