NFL Week 3 odds: Brady, Rodgers meet for potential last clash
Tom Brady and Aaron Rodgers may be meeting for the final time. Photo by Mark LoMoglio/AP.

If you're a fan of comebacks, spoilers, and high-scoring football games, then Week 2 of the NFL season will be hard to top. But football fans should have several matches on the upcoming card circled.

The latest: This Sunday may bring forward the final clash between Tom Brady and Aaron Rodgers. The AFC East battle between the Miami Dolphins and Buffalo Bills just got a whole lot more interesting, too. Russell Wilson, meanwhile, faces a familiar foe in primetime.

Check out the NFL Week 3 odds.

NFL Week 3 odds

Visit all our NFL betting markets and get full odds for Week 3.

DateAwayHomeSpreadO/U
Sept. 25JaguarsChargersLAC -3.542.5
Sept. 25FalconsSeahawksSEA -142
Sept. 25PackersBuccaneersTB -142
Sept. 25RamsCardinalsLAR -3.548.5
Sept. 2549ersBroncosSF -1.544
Sept. 26CowboysGiantsNYG -139

Odds as of 8:11 a.m. ET on 09/25/2022.

NFL Week 3 odds

Matchup of the Week: Green Bay Packers vs. Tampa Bay Buccaneers (-1)

Rodgers and Brady will meet for the fifth and likely final time this Sunday.

The two are the oldest signal callers still in the game and are the last of the elite passers still doing it from their generation. Brady has bested Rodgers in three of their four meetings, but none garnered more attention than their last.

Green Bay's infamous decision to kick a field goal while inside Tampa Bay's 10-yard line and trailing by eight points late in the 2020 NFC Championship Game still haunts Cheeseheads.

It was a missed opportunity for the Packers to cash in on the twilight years of Rodgers' storied career. It also catapulted Brady to his seventh Super Bowl championship.

Fast forward to now, though, and there are a lot of questions surrounding both teams ahead of this matchup. The first thing on everyone's mind is, what's up with Brady? The Buccaneers are 2-0 but the all-time touchdowns leader has thrown just two scores this season.

The Packers are coming off a win against the Bears, but that's not enough to silence the critics after a lopsided 23-7 loss to the Minnesota Vikings in Week 1.

Similarly to Brady, Rodgers has just two passing touchdowns and no wide receiver has more than six receptions.

Both of these elite talents are firmly in their final chapters. Who will win in what may just be their last duel?

Other notable NFL Week 3 matchups

San Francisco 49ers (-1.5) vs. Denver Broncos

It appears that we're going to go through another football season without knowing the answer to the Trey Lance vs. Jimmy Garoppolo debate.

The highly touted sophomore QB will undergo season-ending ankle surgery after suffering an injury in the team's 27-7 win over the Seattle Seahawks. Lance went 2-of-3 for 30 passing yards with 13 rushing yards before exiting the game.

Garoppolo entered and did his thing. He went 13-of-21 for 154 passing yards, one passing touchdown, and a rushing score in the victory. It wasn't a perfect performance by any stretch, but he guided San Francisco to victory against an uninspiring Seahawks squad.

The Broncos underwent a QB change this offseason but the results haven't been as advertised.

Wilson has thrown just two touchdown passes and Denver hasn't scored more than 16 points in either of its games despite facing the Seahawks and Houston Texans.

If there's any good news for Broncos fans, though, it's that Wilson has dominated the 49ers in the past. As divisional rivals, Mr. Unlimited went 16-4 against San Francisco with a 36:10 TD to INT ratio.

This feels like a must-win for Denver as patience is already growing thin for first-time head coach Nathaniel Hackett.

Week 3 notes

  • There was significant line movement in the matchup between the Jaguars and Chargers on Friday. Los Angeles dropped from seven-point favourites to 3.5-points as the questions continue to swirl around Justin Herbert's availability for the game. Chase Daniel would start in his place if Herbert is unable to go, and that's a significant drop-off.
  • There's a four-way tie in the NFC West standings through two weeks, but that'll change this Sunday when the Los Angeles Rams host the Arizona Cardinals. Neither of these playoff teams from a season ago has looked overly impressive. Both squads were crushed in Week 1 before earning narrow victories in Week 2.
  • Monday Night Football pins the Dallas Cowboys against the New York Giants. After all seemed lost in Big D, Cooper Rush led the team to a stunning 20-17 win over the Cincinnati Bengals. The Giants, meanwhile, are surprisingly 2-0 after downing the Tennessee Titans and Carolina Panthers.
NorthStar Bets editorial Insiders have no influence, direct or otherwise, over the setting of odds advertised on our platforms.