UFC 280 odds: Oliveira and Makhachev headline a stacked card
Charles Oliveira and Islam Makhachev square off for the lightweight title on October 22. Photo by Chase Stevens/AP.

UFC 280 will take over Etihad Arena in the United Arab Emirates on Saturday, October 22.

The latest: Two titles are at stake in a stacked five-fight card. Charles Oliveira and Islam Makhachev go toe-to-toe for the vacant lightweight belt while Aljamain Sterling and T.J. Dillashaw touch gloves for the bantamweight title.

Check out the full UFC 280 odds below.

UFC 280 odds

Check out the latest odds for UFC 280. Click linked odds to add selection to betslip.

FighterOddsWeight classOddsFighter
(1) Charles Oliveira+138Lightweight-175(4) Islam Makhachev
(C) Aljamain Sterling-175Bantamweight+138(2) T.J. Dillashaw
(1) Petr Yan-286Bantamweight+225(12) Sean O'Malley
(6) Benil Dariush+155Lightweight-195(9) Mateusz Gamrot
(1) Katlyn Chookagian+175Women's flyweight-225(7) Manon Fiorot

Odds as of 2:52 p.m. ET on 10/19/2022.

UFC 280 odds: Oliveira vs. Makhachev

Odds: Oliveira (+138) vs. Makhachev (-175)

This is shaping up to be one of the most hyped title fights in UFC history.

Makhachev could finally reach the summit while Oliveira has an opportunity to remind everyone why he's regarded as an all-time great.

Let's start with the favourite, Makhachev, who has been terrorizing the lightweight division for the past seven years and holds a UFC record of 11-1 with seven finishes. His only professional defeat was way back in 2015 against Adriano Martins and that was debatably an early stoppage.

The 31-year-old has finished four straight opponents en route to his title bid, though some doubts have been raised about the level of his competition.

Oliveira is by far the best opponent Makhachev will have faced in his career and comes in as a modest +135 underdog. He's also looking to get his belt back.

The Brazilian's lightweight title was stripped ahead of UFC 274 when he missed weight by a half-pound, but he still submitted Justin Gaethje, extending his UFC records in finishes (19) and submissions (16).

Oliveira has won 11 straight UFC fights, dispatching the likes of Tony Ferguson, Dustin Poirier and Michael Chandler all by finish.

Makhachev has the advantage of fighting in Abu Dhabi and will be cornered by Khabib Nurmagomedov.

Sterling vs. Dillashaw

Odds: Aljamain Sterling (-175) vs. T.J. Dillashaw (+138)

Sterling looks to defend his bantamweight title for a second consecutive time.

He first claimed the belt in controversial fashion after Petr Yan was disqualified for an illegal knee in the fourth round of their title fight. He and Yan met for a much-anticipated second go, where Sterling again won, this time by split decision.

Dillashaw looks to win the bantamweight championship for a third time after claiming the title in 2014 and 2018. His latter title was stripped following a positive PED test. Dillashaw was reinstated in 2021 and won his first fight back against Cory Sandhagen.

It's a bit odd to see him fighting for a belt this early into his comeback. That said, a thin bantamweight division and the apprehension of a Sterling vs. Yan trilogy serve as good reasons to have him on this card.

Yan vs. O'Malley

Odds: Yan (-286) vs. O'Malley (+225)

Yan feels it should be him, not Sterling, in the bantamweight title fight.

He didn't mince words after his disqualification against Sterling in 2021 and also believes he should've won the rematch at UFC 273 in April.

Those results can't be changed, so Yan's only course of action will be smashing one of the UFC's biggest rising stars and forcing Dana White's hand.

O'Malley has garnered the MMA community's attention for his eccentric personality and clinical finishes. He has won each of his last five fights by knockout, three of which took place in the opening round.

He's going to be hard-pressed to win by knockout, though. The Russian has never been finished in his career and his only two UFC losses have come to Sterling.

Both fighters throw punches at a blistering pace, so expect to see a high-octane bout.

Dariush vs. Gamrot

Odds: Dariush (+155) vs. Gamrot (-195)

This is another intriguing lightweight fight.

Dariush and Gamrot are on sizeable winning streaks, with the former collecting seven straight victories and the latter riding a four-fight heater.

Both fighters have the ability to finish by either knockout or submission, too. Dariush has won 13 fights by finish (five KO, eight SUB), though both of his last two wins came via decision. Gamrot packs more of a punch, winning seven fights by KO and five by submission.

The winner of this bout could be in line for a title fight in the near future.

Chookagian vs. Fiorot

Odds: Chookagian (+175) vs. Fiorot (-225)

The opening fight of this stacked card isn't a throwaway.

Chookagian is on a four-fight winning streak, with each of those coming by way of decision. She's a solid fighter and is the No. 1-ranked flyweight behind Valentina Shevchenko. A win here would guarantee her a title bout, but most of the attention will be on her opponent.

Fiorot lost her debut fight in 2018 but has rattled off nine straight victories since, four of which were in the UFC.

She's knocked out six of those opponents and lands 5.61 significant strikes per minute compared to Chookagian's mark of 4.56.

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